轮状病毒肠炎心肌损害的分析

摘要

Objective To investigate possible myocardial damage in rotavirus enteritis .Methods Accord-ing to the rotavirus detection test , 131 children with diarrhea were divided into the observation group ( rotavirus posi-tive, n=62) and the control group(rotavirus negative, n=69).The severity of diarrhea, signs of cardiac damages, ECG/chest X-ray, the elevation of myocardial enzymes and troponin T were compared between the two groups .Re-sults There were no significant differences between the two groups in severity of diarrhea , signs of cardiac damage ( P>0.05 ) .There were more elevated CK and CK-MB in the observation group than those in the control group ( P<0.05 ) .There was only one case with weak positive troponin T in the observation group .ECG and chest X-ray exami-nation did not show the specific changes of myocardial damage in the two groups .Conclusion Myocardial damage is infrequent in rotavirus enteritis and there might be false positive results for the detection of CK -MB by immunosup-pression.%目的：探讨轮状病毒肠炎是否更容易导致心肌损害。方法对131例急性腹泻病患儿检测大便中的轮状病毒，阳性62例作为观察组，阴性69例作为对照组，对比两组腹泻病情、心肌损伤相关症状和体征、心电图和影像学改变、心肌酶和肌钙蛋白T的生化检测。结果两组腹泻病情方面比较差异无统计学意义（ P＞0．05）；与心肌损害相关症状和体征差异无统计学意义（ P＞0．05）；观察组血清肌酸激酶（ CK）、肌酸激酶同工酶（ CK－MB）活性（免疫抑制法）水平较对照组明显升高（ P＜0．05），但肌钙蛋白T仅1例弱阳性。心电图和影像学无心肌损害特异性改变。结论轮状病毒肠炎并不容易导致心肌损害，用免疫抑制法测定的CK－MB水平可能存在假阳性。