Objective To investigate the clinical effect of metformin combined with ethinylestradiol and cyproterone acetate tablets in treatment of polycystic ovary syndrome. Methods The data of 57 patients with polycystic ovary syndrome were collected in our hospital from July 2014 to February 2016 and were retrospectively analyzed. The patients were randomly divided into the observation group(n = 30) and the control group(n = 27). The control group was treated with ethinylestradiol and cyproterone acetate tablets,and the observation group was treated with ethinylestradiol and cyproterone acetate tablets plus metformin. Results The ovulation rate and pregnancy rate of the observation group were higher than those of the control group(93. 33％ vs 81. 48％,83. 33％ vs 55. 56％). After treatment,the improvements of sex hormones in the observation group were significantly better than those in the control group(P < 0. 01). No obvious adverse reactions were found in the two groups. Conclusion Metformin combined with ethinylestradiol and cyproterone acetate is effective in treatment of polycystic ovary syndrome. It can better improve the level of sex hormones and improve the ovulation rate and pregnancy rate in the patients.%目的 探讨二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征的临床效果.方法 回顾性分析2014-07 ～ 2016-02该院收治的57例多囊卵巢综合征患者的临床资料.随机将患者分为观察组(n = 30)和对照组(n = 27), 两组患者均给予炔雌醇环丙孕酮片治疗,观察组在此基础上加入二甲双胍治疗.结果 观察组的排卵率和妊娠率分别为93. 33％、83. 33％,均高于对照组的81. 48％、55. 56％; 观察组治疗后性激素水平各指标均明显优于对照组(P < 0. 01); 两组患者在治疗中均未见明显的不良反应.结论 二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征能够更好地改善患者的性激素水平,并提高患者的排卵率和妊娠率,值得在临床中应用推广.
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