成人创伤后应激障碍海马体积研究的Meta分析

摘要

目的 综合评价成人创伤后应激障碍(Posttraumatic stress disorder,PTSD)的左、右侧海马体积.方法 利用Meta分析方法对国内外公开发表的关于成人PTSD左、右侧海马体积的研究文献进行综合定量分析.结果 共收集到符合纳入标准的文献23篇,累计病例共337例,累计对照共389名.PTSD组与健康对照组左侧海马体积分析显示,总体效应检验有统计学意义(Z=4.77,P<0.01),95%CI横线位于无效竖线左侧.提示PTSD的左侧海马体积减小;PTSD组与健康对照组右侧海马体积比较分析显示,总体效应检验有统计学意义(Z=5.01,P<0.01),95%CI横线位于无效竖线左侧,提示PTSD的右侧海马体积减小.漏斗图分布呈倒漏斗形,近似对称,Begg检验证实发表无偏倚.结论 成人PTSD患者左、右侧海马体积均减小.%Objective To comprehensively evaluate the association of hippocampal volumes in adults with post-traumatic stress disorder. Methods All the published studies on the hippocampal volumes and posttraumatic stress disorder were retrieved and standard techniques of meta-analysis to combine with the results of these studies were used to produce a more precise estimate. Results Based on the criteria. 23 studies were selected with a total of 337 accumulative cases and 389 controls. Meta-analysis results showed that compare the hippocampal volumes of controls, the overall effect value of the left (z = 5.01) and right (z = 4.77) in PTSD was statistical significant (P < 0.01). Inverted funnel plot and Begg's test showed the publication bias was not significant (P > 0.05). Conclusions The right and left hippocampal volumes in adults were smaller in the posttraumatic stress disorder group compared to the control group.