神经性厌食患者5-羟色胺2A受体基因多态性与人格特性的关联研究

摘要

Objective To explore the relationship between 5-HT2A 102T/C polymorphism and personality traits in patients with anorexia nervosa. Methods The Multiplex SNaPshot SNP genotyping technique was used to analyze the genotypes of 5-HT2A 102T/C polymorphism and Minnesoda Multiphasic Personality Inventory (MMPI) was applied to measure the personality traits in 107 Chinese Han patients with anorexia nervosa. Results There were significant differences in the Pd (Psychopathic Deviate) T scores among the three genotype subgroups, i.e. C/C, T/T and T/C subgroup, of 5-HT2A 102T/C polymorphism (F = 7.698, P = 0.001). The Pd T scores was significantly higher in the homozygote genotype of both C/C and T/T (67.3 ± 12.7; 65.8 ± 12.7)than in either normal controls or in heterozygote genotype of T/C (58.2 ± 9.8) (P = 0.001 and P = 0.005, respectively). Conclusions S-HT^ 102T/C polymorphism is probably related with the susceptive personality traits of anorexia nervosa. The Pd T score of MMPI is the probable personality endophenotype in anorexia nervosa.%目的 探讨5-羟色胺2A(5-HT2A)受体基因102T/C多态性与神经性厌食患者人格特性之间的关系.方法 应用多重碱基延伸SNP分型技术,对107例神经性厌食患者进行5-HT2A 102T/C基因多态进行检测,并进行明尼苏达多项人格调查表(Minnesoda Multiphasic Personality Inventory,MMPI)评定.结果 5-HT2A 102T/C的三种多态基因型的Pd(心理病理性偏离)量表T分差异有统计学意义(F=7.698,P=0.001);其中,纯合子C/C和T/T基因型Pd量表T分(67.3±12.7;65.8±12.7)均高于中国常模(60),并均显著高于杂合子T/C基因型的Pd量表T分(58.2±9.8)(P1=0.001;P2=0.005).结论 5-HT2A102T/C基因多态可能与神经性厌食的易感人格特性存在关联,MMPI中Pd量表T分很可能是神经性厌食的人格特性内表型.