高压氧对沙土鼠脑缺血再灌注海马神经细胞NMDA受体的作用研究

摘要

显,但显著高于假手术组(P<0.01).结论 脑缺血后,海马区神经细胞NMDA受体的Bmax显著增加,氯胺酮、氯胺酮+高压氧治疗可使Bmax降低.可能通过此途径减少细胞外Ca2+内流,恢复细胞内游离Ca2+浓度,从而起到高压氧治疗脑缺血的作用.%x, which might reduce entry of Ca2+ into cells during ischemia and reperfusion, and at the same time, restore concentration of intracellular calcium [Ca2+]. All this might account for the therapeutic effect of HBO on cerebral ischemia.