Objective To explore the effect of medication adherence therapy on the survival status of patients with primary depression.Methods From July 2011 to December 2013, 55 cases of depression patients in our hospital were treated as control group, and routine health education was implemented. From January 2014 to June 2016 in our hospital and the 57 first treatment of depression patients choosing for observation group, received the routine care and the implementation of medication adherence for the treatment method of education. The scores were assessed in SDS score at 3 months and 6 months after admission, the quality of life score at admission and 6 months after intervention, and the compliance of treatment at 6 months after the intervention. Results At the time of admission of two groups patients with depression score difference was not statistically significant (t=1.124,P=0.059); after interventions for 3 months and 6 months in the observation group, the patients with depression scores were significantly lower than that of the control group, and the difference was statistically significant (t=3.986, 8.532;P<0.01). The implementation of drug compliance therapy intervention, observation group of patients in the medication compliance, timely review, reasonable rest, reasonable diet, reasonable exercise, prevention of infection, smoking and drinking in 7 dimensions and total score were significantly higher than those of the control group,and there was significant difference between two groups (t= 6.022, 6.954, 5.863, 5.042, 6.514,5.652, 4.675, 5.868;P<0.01). Patients in the observation group in physiological function, psychological function, social function, health self cognition and total quality of life scores improved significantly higher than that in the control group, and the differences were statistically significant (t=5.265, 4.638, 4.267, 4.146, 3.955;P<0.01).Conclusions Medication adherence therapy can improve the treatment compliance of patients, reduce the degree of depression, and improve the quality of life of patients.%目的 探讨药物依从性疗法对初发抑郁症患者生存质量的影响.方法选择2011年7月—2013年12月在笔者所在医院住院且首次治疗的抑郁症患者55例为对照组,实施常规健康教育.选择2014年1月—2016年6月笔者所在医院住院且首次治疗的抑郁症患者57例为观察组,在常规护理的基础上实施药物依从性疗法.分别测评患者入院时、干预3个月和干预6个月后的SDS评分;入院时和干预后6个月时的生存质量评分;干预后6个月时的治疗依从性.结果入院时两组患者的抑郁评分差异无统计学意义(t=1.124,P=0.059);干预3个月和6个月后观察组抑郁评分均明显低于对照组,差异有统计学意义(t值分别为3.986、8.532;P均<0.01).干预后,观察组在用药依从性、按时复查、合理休息、合理饮食、合理锻炼、预防感染、戒烟戒酒7个维度及总评分方面均明显高于对照组,两组差异有统计学意义(t值分别为6.022、6.954、5.863、5.042、6.514、5.652、4.675、5.868;P均<0.01).观察组在生理功能、心理功能、社会功能、健康自我认识能力及总生活质量方面的得分改善情况均优于对照组,差异均有统计学意义(t值分别为5.265、4.638、4.267、4.146、3.955;P均<0.01).结论药物依从性疗法可提高患者的治疗依从性,缓解患者的抑郁情绪,提高患者的生存质量.
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