复方螺旋藻片对高血脂症小鼠血脂的影响

摘要

To study the effect of Spirulina Com pound Tablet(FST) on the level of serum lipids in hyperlipidemic mice.METH ODS:The experimental hyperlipidemic mice were divided into four groups.Amo ng them,two groups were treated with FST 1.5g/kg,3g/kg respectively by ig admini stration,and one group was given lipanthyl 0.05g/kg by ig administration as the positive drug control,another group was received physiological saline by ig admi nistration as the hyperlipidemic control.The treatment were consecutively carrie d out for 14 days.Then the serum lipids of each group were determined with autom atic biochemistry analysor.RESULTS:Compared with the hyperlipidemic control group,it was found that FST could significantly decrease the level of to tal serum cholesterol(TC),triglyceride(TG),and low density lipoprotein-choleste rol(LDL-C),as well as remarkably increase the content of serum high density lip oprotein-cholesterol(HDL-C) and the value of HDL-C/TC in the hyperlipidemic m ice.Furthermore,the results also showed that FST could obviously raise the conce ntration of the serum apolipoproteinAI(apoAI) and reduce the concentration of ap olipoproteinB(apoB)(Whereas FST 1.5g/kg had no significant effect on apoB).CONCLUSION:FST could remarkably decrease the content of serum lipids and regulate the apolipoprotein in the hyperlipidemic mice.%目的：观察复方螺旋藻片(FST)对高脂血症小鼠血脂的影响。方法：用FST 1.5mg/kg,3g/kg分别灌胃给予高脂血症小鼠，连续14d后，眼眶 取血测血脂。结果：与高脂血症模型对照组相比，FST高、低剂量能显著 降低血清TC、TG和LDL-C水平，明显升高血清HDL-C水平与HDL-C/TC比值。同时FST还能升 高血清apoAI并降低apoB(但FST 1.5g/kg对apoB无明显影响)。结论：FST 能明显降低高脂血症小鼠血脂水平，并对载脂蛋白有一定的调节作用。