复方碳酸钙泡腾颗粒剂人体相对生物利用度研究

摘要

OBJECTIVE：To study the relative bioavailability of compound calcium carbonate granules in Human.METHODS:Comparing with caltrate D 600 tablets,the cumulate amount of calcium in urine was determined with atomic absorption spectrophotometer after taking compound calcium carbonate granules and caltrate D for 12 volunteers.RESULTS:The average excreteive calcium qualities in urine in three gorups,compound calcium carbonate granules and caltrate D tablets and blankness volunteer groups,were orderly 125.21±26.60,124.49±36.60 and 67.31±19.39mg in 12 hours.Comparing with the space group,the increasing amount of calcium in extracted urine were 57.97±24.24mg in compound calcium carbonate granules and 57.31±32.68mg in caltrate D tablets groups.The releative bioavaillability of compound calcium carbonate granules in human was 101.5%.There was no remarkable differentias between two groups(P＞0.05).CONCLUSION:According to the urinous drugs excretive rate methods,there was similar absorption rate between two test drugs.%目的：考察复方碳酸钙颗粒剂的人体相对生物利用度。方法：以钙尔奇D600为对照品，原子吸收分光光度法测定12名自愿受试者口服复方碳酸钙颗粒剂后的尿钙排泄量。结果：在12h内，复方碳酸钙颗粒剂组，钙尔奇D组和空白对照组的平均尿钙排泄总量分别为125.21±26.60,124.49±36.60和67.24±19.39mg。集尿期内复方碳酸钙颗粒剂和钙尔奇D尿钙排泄总量的净增值分别为57.97±24.24和57.31±32.68mg。复方碳酸钙颗粒剂的相对生物利用度101.50%。结论：两种药物的吸收程度相当，无统计学差异(P＞0.05)，由尿钙排泄速率推测，复方碳酸颗粒剂的吸收速度与钙尔奇D片一致。