原发性中枢神经系统神经母细胞瘤临床特征及预后分析

摘要

Objective To investigate the clinical characteristics and prognosis of primary neuroblastoma in the central nervous system. Methods Clinical data of 8 patients with primary neuroblastoma in the central nervous system who underwent microsurgery were analyzed retrospectively, among whom 4 patients received radiotherapy, one chemotherapy, and one chemoradiotherapy after surgery. Results Complete tumor resection was achieved in 4 cases, subtotal resection in 3 and partial resection in 1. All the patients were diagnosed as having primary cerebral neuroblastoma by postoperative pathological analysis. Eight patients were followed up for a mean period of 21 months. Tumors recurred in 5 patients, and the mean interval of recurrence was 8 months. Among the recurrent patients, 4 died and the mean survival time was 24.5 months, and one is still alive. Conclusions Primary cerebral neuroblastoma is rare and can be confirmed by postoperative pathology. Complete tumor resection combined with adjuvant chemoradiotherapy is a good mean for the treatment of primary neuroblastoma in the central nervous system.%目的 探讨原发性中枢神经系统神经母细胞瘤的临床特征及预后.方法 回顾性分析采用手术治疗的8例原发性中枢神经系统神经母细胞瘤病人的临床资料,其中术后行单纯放疗4例,单纯化疗1例,放化疗1例.结果 肿瘤全切4例,近全切除3例,部分切除1例.术后均经病理确诊为原发性中枢神经系统神经母细胞瘤.随访8例,中位随访时间21个月.术后复发5例,中位复发时间8个月,其中死亡4例,中位生存期24.5个月,存活1例.结论 原发性中枢神经系统神经母细胞瘤临床罕见,需通过病理确诊.治疗宜采用肿瘤全切除术,术后辅助放化疗.