Objective To investigate the clinicopathological features of meningioangiomatosis (MA) associated with meningioma. Methods Clinical data of 1 patient with MA associated with meningjoma was analyzed retrospectively. The pathological morphology observation and immunohistochemistry were performed in the patient, and the results were analyzed with the literature review. Results Microscopic observation: the brain cortex revealed numerous abnormal intracortical blood vessels, which were cuffed by meningothelial cell and fibroblast-like spindle cell. Collagenzation and hyalinization occurred in part of great vessels with calcification and psammoma bodies, and transitional meningioma component could be seen. The degenerative neuron and gliosis were observed in the lesion. Immunohistochemistry results: vimentin was positive, and EMA was positive partly. The positive rate of Ki-67 was 3% in the meningioma area and less than 1% in the MA area. Conclusions MA is a rare benign lesion in brain, which usually locates in frontal and temporal lobe and affects the surrounding meningocyte. MA with meningiomas is quite rare, which need to discern from invasive meningioma, solitary fibrous tumor, encephalic schwarmoma and so on in morphologic structure.%目的 探讨脑膜血管瘤病(MA)合并脑膜瘤的临床病理特点.方法 回顾性分析1例颅内MA合并脑膜瘤病人的临床资料,行病理形态学观察及免疫组织化学检测,并对该病进行文献复习.结果 光镜观察:皮质内血管增生,脑膜上皮细胞及梭形的纤维母细胞样细胞围绕血管排列,部分大血管明显胶原化及透明变性,伴钙化或砂砾体形成,且可见明显的过渡型脑膜瘤成分,病灶内残留变性神经元和胶质细胞增生.免疫组化染色显示:vimentin阳性,上皮细胞膜抗原(EMA)局灶性阳性,Ki-67阳性率在脑膜瘤区域约为3％,在脑膜血管瘤病区则＜1％.结论 MA是--种少见的良性病变,病变通常位于大脑额颞叶皮质并可累及周围脑膜组织,MA合并脑膜瘤更少见,在形态学上应与侵袭性脑膜瘤、孤立性纤维瘤、颅内神经鞘膜瘤等鉴别.
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