Objective To study the differences in efficacy and complications between single and fractionated therapy by X-knife for pituitary adenomas. Methods Clinical data of 121 patients with pituitary adenomas treated by X-knife were analyzed retrospectively, and divided into single therapy group (n = 70) and fractionated therapy group (n = 51) according to the treatment methods. The differences in efficacy and complication rates between two groups were compared. Results Overall tumor control rate was 95.9% after treatment, including 67 patients (95.7%) in single therapy group and 49 (96.1%) in fractionated therapy group. The control rate of hormone level after treatment was 38.0%, including 28 patients (40.0%) in single therapy group and 18 (35.3%) in fractionated therapy group. There were no statistically significant differences in control rates of tumor and hormone level between the two groups (P > 0.05), while there was a statistically significant difference in the complication incidence of grades 1, 2, 3 between the two groups (P < 0.05). Conclusion Fractionated therapy with proper treatment intervals is a reliable method for reducing the complications of pituitary adenomas.%目的 探讨垂体腺瘤行X-刀单次治疗与分次治疗后疗效与并发症的差异.方法 回顾性分析121例经X-刀治疗的垂体腺瘤病人的临床资料,根据治疗方式不同分为单次治疗组(70例)与分次治疗组(51例),比较两组疗效及并发症发生率的差异.结果 治疗后总体肿瘤控制率为95.9％,其中单次治疗组肿瘤控制67例(95.7％),分次治疗组肿瘤控制49例(96.1％);治疗后激素水平控制率为38.0％,其中单次治疗组激素水平控制28例(40.0％),分次治疗组激素水平控制18例(35.3％);两组肿瘤控制和激素水平控制差异均无统计学意义(P ＞0.05).而治疗后两组l、2、3级并发症发生率差异均有统计学意义(P＜0.05).结论 适当的治疗间隔时间的分次治疗是降低并发症的可靠方法.
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