髓系细胞触发受体-1与动脉粥样硬化系的研究进展

摘要

髓系细胞触发受体-1(TREM-1)是新近发现的免疫球蛋白超家族活化跨膜受体,能够触发和扩大炎症反应,在动脉粥样硬化(AS)的炎症机制中起重要作用.本文从TREM-1的结构特点、表达方式、配体结合、信号通路等论述其与AS发生发展及动脉斑块稳定性的关系和作用,为临床研究AS的靶向治疗提供参考和借鉴.%The triggering receptor expressed on myeloid cells-1 (TREM-1) that can trigger and expand inflammatory response is a newly discovered activating transmembrane receptor of immunoglobulin superfamily,and it plays a key role in atherosclerosis (AS).To provide a reference or clue for targeted therapy of AS in clinical research,this review discusses effects of TREM-1 on development of AS and artery plaque stability from its structural characteristics,expression,ligand binding,signaling pathways et al.