Objective To observe the effect of Ganoderma lucidum spore powder on sugar tolerance and intestinal flora of diabetes rats induced by streptozotocin (STZ). Methods The diabetes model rats (divided into 2 groups: the therapy group and the control) were intragastric administration with equal volume of Ganoderma lucidum spore powder and distilled water for 10 weeks, respectively. Then the blood glucose level and intestinal flora amount were tested. Results The abnormal sugar tolerance of therapy group rats returned to normal and the amount of Bacillus bifidus in intestinal flora also recovered. There were significant differences compared with control. Conclusion Canoderma lucidum spore powder can decrease blood sugar level and adjusts intestinal flora amount of experiment rats.%目的 观察灵芝孢子粉对链脲佐菌素(STZ)糖尿病大鼠糖耐量和肠道菌群的影响.方法 将用STZ诱导的糖尿病模型大鼠分为灵芝治疗组和模型对照组,分别灌胃灵芝孢子粉(每天250mg/kg)和等体积的蒸馏水,连续10周,而后检测两组大鼠血糖及肠道菌群的变化.结果 治疗组大鼠糖耐量基本恢复正常,肠道菌群中的双歧杆菌数量有所回升,与对照组比较,差异有统计学意义(P<0.05).结论 灵芝孢子粉对实验大鼠有一定降血糖及菌群调节作用.
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