T-Synthase活性对胃癌Tn/STn及T/ST抗原表达的影响

摘要

胞;Tn+细胞同时表达Tn/STn抗原,不表达T/ST抗原,Tn-Ⅰ及Tn-细胞均表达ST抗原,部分Tn-Ⅰ细胞可见T抗原表达;Tn+、Tn-Ⅰ及Tn-细胞间T-Synthase mRNA无明显差别,T-Synthase活性在Tn+细胞明显下降.结论 不同TNM期胃癌组织中Tn、STn、T、ST抗原表达存在差异,T-Synthase活性降低可能导致胃癌细胞表达Tn抗原.%acts was much lower than that in Tn-cell.Conclusion The expression of Tn,STn,T and ST antigen in gastric carcinoma tissues of different TNM stages is different.Tn antigen expression in tumor cells may be caused by the decrease of T-Synthase activity.