床旁快速检测对老年慢性阻塞性肺疾病急性加重期患者预后评估的价值

摘要

Objective To investigate the value of rapid bedside testing of D-Dimer, PCT, CRP and cTnI on the prognosis of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) in senile patients.Method A total of 82 senile patients with AECOPD were prospectively studied,and divided into two groups, namely remission group and death group according to prognosis. Serum D-Dimer, CRP, PCT and cTnI were assayed, the differences in those indicators between two groups were analyzed; and the correlation between Serum D-Dimer, CRP, PCT, cTnI and prognosis were investigated.ResultCompared with death group,there were significant differences in D-Dimer, PCT, CRP and cTnI levels in the remission group. The levels of D-Dimer, CRP and PCT in the remission group one were higher than those in the remission group two, the difference was statistically significants.ConclusionRapid bedside testing of D-Dimer, CRP, PCT and cTnI, is useful for the evaluation of prognosis of AECOPD in senile patients.%目的床旁快速检测指标D-二聚体（D-Dimer）、C反应蛋白（C-reactive protein，CRP）、降钙素原（procalcitonin， PCT）和肌钙蛋白I（cardiac trooping I，cTnI）在老年慢性阻塞性肺疾病急性加重期（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）的变化，评价其在预后评估中的作用。方法选取老年AECOPD患者82例，根据预后分为缓解组与死亡组，比较不同组间D-Dimer、CRP、PCT和cTnI水平；缓解组病例随访6个月，根据有无事件发生将缓解组分为缓解组1和缓解组2，并比较两组间D-Dimer、CRP、PCT及cTnI水平差异。结果缓解组D-Dimer、CRP、PCT、cTnI水平与死亡组比较差异存在显著性（P＜0.05）；缓解组1 D-Dimer、CRP、PCT水平均高于缓解组2，差异有显著性（P＜0.05）。结论监测老年AECOPD患者快速床旁检测指标D-Dimer、CRP、PCT和cTnI水平，有助于判断患者临床预后。