目的：探讨GlifeetR检查餐在结肠内镜黏膜下剥离术（endoscopic submucosal dissection，ESD）患者肠道准备中应用的效果和安全性。方法采用单盲、随机、对照试验方法，将20例行结肠ESD的患者分为两组，常规饮食组（n=10）及GlifeetR检查餐组（n=10）。口服清肠药的时间和剂量不变，观察两组肠道清洁度及不良反应。结果检查餐组患者服用清肠液后第1次排便时间较常规饮食组明显缩短（P=0.041）；排便次数多于常规饮食组（P=0.063），但两组差异无显著性。波士顿评分检查餐组略优于常规饮食组，但两组差异不具有显著性。检查餐组右侧结肠清洁度评分优于常规饮食组（P=0.045）。检查餐组患者依从性优于常规饮食组，两组均无严重不良反应发生。结论在结肠ESD操作前服用GlifeetR检餐进行肠道准备，有利于改善肠道清洁度，提高患者饮食准备的依从性。%ObjectiveTo investigate the role of GlifeetR in bowel preparation before endoscopic submucosal dissection(ESD).Method This is a prospective, blinded, randomized controlled trial of patients undergoing ESD. A total of 20 inpatients were randomized to either (a) a low-residue diet for breakfast, lunch and dinner (n=10) or (b) GlifeetR all day (n=10) the day before the procedure. All patients underwent an identical polyethylene glycol electrolytes powder split preparation. Bowel preparation quality was scored using the Boston bowel preparation scale (BBPS). Side effects were also observed.Result The time of the first bowel movement of group b was significantly shortened (P=0.041). An increased defecating frequency was observed in group b, but there was no significant difference when compared with group a (P=0.063). BBPS was equivalent between both groups. But the bowel preparation quality of the right colon was significantly better in group b (P=0.045). Patient tolerance and acceptance was good in group b. There were no severe adverse events in both groups. Conclusion GlifeetR is suitable for bowel preparation before ESD. It was simple, well tolerated by the patients, and partially improved the quality of bowel preparation.
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