血清EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA与鼻咽癌的相关性分析

摘要

Objective This study was perform to investigate the clinical evaluation of serum EA-IgA, VCA-IgA, Rta-IgG and EBV-DNA in the diagnosis of nasopharyngeal carcinoma. Method Serum EA-IgA, VCA-IgA, Rta-IgG and EBV-DNA levels were measured in 218 specimens of patients, including 50 patients with VCA-IgA positive, 50 patients with rhinitis and 50 controls, respectively. Result The sensitivity of EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA was31.37%、76.47%、67.65%,64.71%, respectively, the specificity was 96%、94%、98%、98%, respectively. With combined detection of EA-IgA and VCA-IgA, the sensitivity would be 75% and specificity would be 94%; With combined detection of EA-IgA、VCA-IgA and Rta-IgG, the sensitivity would be 89.71% and specificity would be 93%; With combined detection of EA-IgA、VCA-IgA and EBV-DNA, the sensitivity would be 88.24% and specificity would be 93%; With combined detection of four markers the sensitivity would be 95.59% and specificity would be 93%. Conclusion Combined measurement of serum EA-IgA, VCA-IgA, Rta-IgG and EBV-DNA levels is of clinical usefulness for diagnosis of Nasopharyngeal Carcinoma.%目的 探讨血清EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA对鼻咽癌的临床诊断价值.方法 选择218份患者血清进行EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA检测,通过对正常人组、VCA-IgA阳性正常人组、鼻炎组和鼻咽癌组患者治疗前血清EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA水平的比较,分析各项指标与鼻咽癌的相关性.结果 以单项指标诊断鼻咽癌时,血清EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA的敏感度分别为31.37%、76.47%、67.65%,64.71%,特异度分别为96%、94%、98%、98%;EA-IgA和VCA-IgA两项联合检测时,敏感度为75%,特异度为94%.以一项指标阳性即判断为阳性:EA-IgA、VCA-IgA和Rta-IgG三项指标联合检测时,敏感度为89.71%,特异度为93%;EA-IgA、VCA-IgA和EBV-DNA三项指标联合检测时,敏感度为88.24%,特异度为93%;四项指标联合检测时,敏感度为95.59%,特异度为93%.结论 血清EA-IgA、VCA-IgA、Rta-IgG、EBV-DNA与鼻咽癌具有相关性,联合检测可提高对鼻咽癌的诊断敏感性.