血管生成素-1与急性期脑梗死灶周围侧支循环建立的相关性研究

摘要

目的探讨血管生成素-1与急性期脑梗死侧支循环建立是否存在相关性。方法收集2014年6月1日至2015年12月31日间本院收治符合入组标准的99例患者的临床资料，根据入院时磁共振脑灌注加权成像（perfusion weighted imaging，PWI）结果，分成脑侧支循环建立组与脑灌注不足组，其中脑灌注不足组又分成尤瑞克林干预组与非尤瑞克林干预组。三组治疗第1天和第10天分别查血管生成素-1水平。结果①治疗第1天与第10天比较：脑侧支循环建立组和尤瑞克林干预组血管生成素-1各自组内比较差异有显著性（P＜0.05），而非尤瑞克林干预组组内差异无显著性（P＞0.05）。②治疗第1天脑侧支循环建立组和灌注不足组血管生成素-1组间比较，尤瑞克林干预组与非尤瑞克林干预组组间比较，差异无显著性（P＞0.05）。③治疗第10天尤瑞克林干预组与非尤瑞克林干预组血管生成素-1组间比较差异无显著性（P＞0.05）。④治疗第1天与第10天血管生成素-1水平增幅组间比较，尤瑞克林干预组与非尤瑞克林干预组差异无显著性（P＞0.05）。⑤治疗第1天血管生成素-1水平与磁共振PWI参数局部脑血容量（regional cerebral blood volume，rCBV）、局部脑血流量（regional cerebral blood flow，rCBF）、平均通过时间（mean transit time，MTT）均无相关性。结论暂未发现血管生成素-1与脑侧支循环建立存在相关性。%ObjectiveInvestigate whether there is correlation between Ang-1 and the establishment of collateral circulation in acute cerebral infarction.Method99 patients were collected, ultimately the 99 cases were into the group. All the patients were performed on the head MR within 24 hours. According to the PWI, all the patients were divided into the cerebral collateral circulation group and the cerebral hypoperfusion group, the latter was divided into the Urinary Kallidinogenase intervention group and non intervention group. All patients were checked the angiopoietin -1 and do it again after 10 days.Result①There was statistically significant difference between 1 day and 10 days both in the cerebral collateral circulation group and the Urinary Kallidinogenase intervention group. But no statistically significant existed in the non urinary kallidinogenase intervention group (P>0.05).②In the first day No statistically significant difference was found between the cerebral collateral circulation group and cerebral hypoperfusion group, so did the Urinary Kallidinogenase intervention group and non intervention group (P>0.05).③There were no statistically differences between the Urinary Kallidinogenase intervention group and non intervention group after 10 days (P>0.05).④The increases between 1 day and 10 day was no statistically significant between the Urinary Kallidinogenase intervention group and non intervention group (P>0.05).⑤The level of the Ang-1 was not correlated with rCBV, rCBF and MTT in the first day.ConclusionThere isn’t correlation between Ang-1 and the establishment of collateral circulation in acute cerebral infarction according to the cases.