血必净注射液对老年重症肺炎患者的临床疗效及安全性观察

摘要

Objective:To observe the clinical efficacy and safety of Xuebijing injection in elder patients with severe pneumonia. Methods:186 elder patients with severe pneumonia were randomly divided into two groups. Patients in the control group were in routine therapy. Treatment of routine therapy combined with Xuebijing Inj ection(intravenous infusion for 7 days) was applied for the treatment group. Differences of Clinical symptoms, the total white cell count, body temperature, PO2, SaO2 and Pao2/FiO2 between before and after the therapy were observed, so were the average days in hospital, function of liver and the platelet count .Results:The total effective rate was 96.4% in the treatment group and 84.6% in the control group,and there was a significant difference between the two groups (P<0.05). There was also a significant difference between the treatment group(7.03 ±3.5 days) and the control group(10.81 ±3.06days) in average days in hospital(P<0.05). Morever, there were significant differences in body temperature on the third day and the seventh day, the total white cell count, PO2, SaO2 and PaO2/FiO2 between the two groups(P<0.05). While there was not a significant difference in liver function and the platelet count (P>0.05).Conclusion:The Xuebijing injection has a definite clinical efficacy and safety on elder patients with severe pneumonia.%目的:观察血必净注射液治疗老年肺炎患者的临床疗效和安全性.方法:将108例老年肺炎患者随机分为治疗组和对照组,对照组给予常规抗感染、祛痰、吸氧、对症支持治疗,治疗组在常规治疗基础上加用血必净注射液100ml/天,静脉滴注,连用7天.比较两组治疗前后临床症状、白细胞总数、体温、PO2、SaO2,及PaO2/FiO2变化,以及两组患者的平均住院日,治疗前后的肝肾功能、血小板变化.结果:治疗组总有效率96.4%,对照组总有效率84.6%,两组差异有显著性(P<0.05),平均住院日治疗组[(7.03±3.51)天]与对照组[(10.81±3.06)天]比较差异有显著性(P<0.05).治疗组治疗后3天和7天的体温、白细胞总数、PO2,SaO2,PaO2/FiO2与对照组相比差异有显著性(P<0.05),两组治疗前后肝肾功能、血小板计数差异无显著性(P>0.05).结论:血必净注射液治疗老年肺炎具有较好的临床疗效和安全性.