中药配合治疗小儿难治性肾病综合征的疗效观察

摘要

Objective:To investigate the clinical effect and application value of traditional chinese medicine combined treatment on refractory nephritic syndrome in children.Methods:256 cases of children with refractory nephritic syndrome were retrospectively analyzed, and divided into observed group and control group of 128 cases. The control group was treated with cytotoxic drugs cyclophosphamide for pulse therapy. In addition to above treatment, the observed group was treated by combining with chinese herbal formula. Observed the change in urinary protein excretion and cholesterol before and after treatment as well as the incidence of adverse reactions.Results:The total effective rate in the observed group and the control group was 97.7%and 91.4%, respectively. The observed group gained even more excellent effect than the control group (x2=4.84, P<0.05). Before treatment, there was no significant difference between the two groups (P>0.05). However, urinary protein excretion and cholesterol in both groups were decreased after treatment and the difference was statistically significant (P<0.01). Moreover, there was more decrease observed in the observed group, and the difference was significant (P<0.01). The incidence of adverse reactions in the observed group and the control group was 0.8%and 6.3%, respectively. The adverse reactions in the observed group was significantly lower than that in the control group (x2=4.15,P<0.05).Conclusion:Chinese medicine combined treatment on refractory nephrotic syndrome in children could achieve a desire effect in clinic. It not only can effectively improve the level of serum albumin, urinary protein excretion and cholesterol, but also reduce the adverse reactions caused by cytotoxic drug therapy. Therefore, it is worthy of further research and applications in clinic.%目的：探讨中药配合治疗小儿难治性肾病综合征的临床效果及应用价值。方法：回顾性分析256例小儿难治性肾病患儿的一般资料,随机分为观察组128例和对照组128例,对照组单纯采用细胞毒类药物环磷酰胺进行冲击治疗,观察组在对照组的基础上,加用中药配方。观察治疗前后尿蛋白定量、胆固醇、不良反应。结果：观察组总有效率97.7%,对照组临床总有效率91.4%,观察组治疗效果明显优于对照组(x2=4.84,P<0.05)；两组患儿治疗前比较无差异(P>0.05),治疗后,两组患儿尿蛋白定量及胆固醇均有所下降,差异具有统计学意义(P<0.01),但观察组患儿下降更为明显,差异显著(P<0.01)；观察组不良反应发生率为0.8%,对照组不良反应发生率为6.3%,观察组不良反应明显低于对照组(x2=4.15,P<0.05)。结论临床采用中药配合治疗小儿难治性肾病效果较为显著,能够有效改善患者的血清白蛋白、尿蛋白定量、胆固醇的含量,还能够降低细胞毒类药物治疗的不良反应,值得临床进一步研究应用。