鬼臼脂素C-环不同结构类型对抗肿瘤活性的影响

摘要

合成了鬼臼脂素C环4-位羟基不同取向、C环芳构化、C环反式和非反式稠合、C环2，3-不饱和、C环3-位引入溴原子等不同结构类型的化合物，并测试了其体外抑制KB细胞和L1210白血病细胞活性。C环结构类型不同，对细胞毒活性影响也不同。%Podophyllotoxin analogues with different structures of ring Cwere synthesized.Their activities against L1210 and KB cells were tested.The structure-activity relationships were discussed.The different structures of ring C can make differences in cytotoxities.