Though computed tomography (CT) is widely used in anatomical imaging, bone imaging, tumor imaging and so on, CT had a low soft-tissue contrast. However, magnetic resonance imaging (MRI) has a high soft-tissue contrast, with a long imaging time and expensive cost. Therefore, CT and MRI can be combined to make complementary advantages for obtaining more accurate biological information in a short time. Nowadays, the relevant review on CT/ MRI bimodal contrast agent is few. Herein we summarized several methods to prepare CT/MRI bimodal contrast agent based on some predecessors of CT/MRI bimodal contrast agent, such as nanoemulsion method, surface physical modification method, surface chemical modification method, chloramine-T iodine labeling method, and oxidation reduction method. Finally, the developments of CT/MRI bimodal contrast agent are prospected.%电子计算机断层扫描(CT)用途广泛,常用于解剖学成像,骨成像和肿瘤成像等,但软组织对比度较低.核磁共振成像(MRI)的软组织对比度高,但成像时间长,价格昂贵.将CT成像技术与MRI技术合二为一使其优势互补,可以在短时间内得到更准确的生物信息.如今CT/MRI双模态造影剂相关的综述文献并不是很多.本文在CT/MRI双模态分子影像前驱物的基础上归纳一些制备CT/MRI双模态造影剂的方法,如纳米乳法,表面物理修饰法,表面化学修饰法,氯胺-T碘标记法,氧化还原法,并展望了未来CT/MRI双模态造影剂的发展.
展开▼
