PET/CT最大标准化摄取值及肿瘤标志物与肺癌预后的关系

摘要

目的 比较PET/CT成像中最大标准化摄取值(SUVmax)及肺癌相关肿瘤标志物水平与肿瘤预后的关系,为非小细胞肺癌的综合评估提供证据.资料与方法回顾性分析179例非小细胞肺癌患者的PET/CT显像与血清癌胚抗原(CEA)、细胞角蛋白19片段抗原(CYFRA21-1)和神经元特异性烯醇化酶(NSE)检测结果,根据临床及病理学特征进行分组,比较不同组间SUVmax与肿瘤标志物水平的差异,及其与肿瘤组织学类型、分化程度、临床分期的相关性.结果 肿瘤大小影响SUVmax高低,肿块最大直径≥3 cm者SUVmax显著高于<3 cm者(P<0.01),肿瘤SUVmax及血清NSE水平与组织分化程度有关,低分化组SUVmax及NSE水平均高于中、高分化组(P<0.05、P<0.01).SUVmax、CEA、CYFRA21-1和NSE与患者性别、年龄、肿瘤病理类型及临床分期无关(P>0.05).结论 SUVmax和NSE与非小细胞肺癌肿瘤分化程度有一定的关系,可以作为间接预测肺癌患者预后的参考指标.%Purpose To compare the relationship between the maximum standardized uptake value (SUVmax) of PET/CT imaging and tumor markers in lung cancer, and to provide evidence for the comprehensive assessment of non small cell lung cancer. Materials and Methods The results of PET/CT imaging, serum carcinoembryonic antigen (CEA), cytokeratin-19 fragment antigen 21-1 (CYFRA21-1) and neuronspecific enolase (NSE) of 179 patients with non small cell lung cancer were analyzed, subjects were then divided into different groups according to their clinical features and pathological types, the differences of SUVmax and tumor markers'' level were compared between different groups, and their correlations with tumor histological type, differentiation and the clinical stages were also analyzed.Results SUVmax of the tumor was related with lesion size,≥3 cm tumors'' SUVmax were significantly higher than that of <3 cm tumors (P<0.01), SUVmax and serum NSE level were related with tumor differentiation, and these in low differentiation group were higher than those in high and medium differentiation group (P<0.05,P<0.01). In addition, SUVmax, CEA, CYFRA21-1 and NSE had no correlation with gender, age, pathological type and clinical stage (P>0.05).Conclusion SUVmax and NSE have a certain relationship with tumor differentiation in non small cell lung cancer patients, thus can be used as a reference index for prognosis of indirect prediction of lung cancer.