Purpose To investigate the 18F-FDG PET/CT manifestation ofextranodal NK/T-cell lymphoma (ENKTCL) for providing important reference for the early diagnosis,accurate staging and guiding treatment of the disease.Materials and Methods The imagings and clinical data of twenty-six patients with nasal ENKTCL were analyzed retrospectively.The diagnosis was confirmed by pathological biopsy and immunohistochemistry.The distribution and metabolic signs of the lesions were summarized,and the influence of PET/CT on nasal ENKTCL staging was analyzed.Results Totally 102 positive lesions were detected in 26 patients.The SUVmax of all lesions was 12.2±5.4 (3.2-28.5).The primary lesions were mainly located in the nasal cavity (16/26,61.5％).Facial soft tissue and paranasal sinus tissue involvement were most common adjacent invasions.The distribution of the remaining affected tissues and organs in the whole body showed no obvious regularity.Lymph node involvement was most common in cervical lymph nodes.The lesion detection rates of PET/CT and conventional imaging (plain scan/enhanced CT,plain scar/ enhanced MRI,ultrasound,etc.) in lymph node and extranodal organ involvement were 96.7％ and 65.5％,respectively,and the accuracy of staging were 92.3％ and 73.1％,respectively.Clinical stages were changed in 15 patients (57.7％)because of PET/CT examination,among which,the staging was improved in twelve cases for finding more lesions,the staging of the suspicious lesions were reduced and the nature was defined in three cases because of their lack of metabolism on the PET/CT,and the treatment plan was affected in nine cases for staging adjustment.Conclusion 18F-FDG PET/CT can accurately show the distribution of nasal ENKTCL lesions.Compared with the conventional imaging methods,more lymph nodes and extranodal organ involvement can be detected by 18F-FDG PET/CT,which makes the staging more accurate and guides the clinical treatment more effectively.%目的 探讨鼻型结外NK/T细胞淋巴瘤(ENKTCL)的18F-FDG PET/CT表现,以期为本病的早期诊断、准确分期及指导治疗提供参考.资料与方法 回顾性分析26例鼻型ENKTCL患者的影像学及临床资料,经病理活检及免疫组化确诊,总结分析病灶的分布及代谢征象,分析PET/CT对鼻型ENKTCL分期的影响.结果 26例患者共检查出阳性病灶102个,所有病灶SUVmax 3.2～28.5,平均12.2±5.4.原发病灶多位于鼻腔(16/26,61.5％),邻近部位侵犯以鼻面部软组织及鼻旁窦最多见.全身其余受累组织器官的分布无明显规律.淋巴结受累以颈部淋巴结最多见.PET/CT与常规影像学检查(平扫/增强CT、平扫/增强MRI、超声等)对淋巴结及结外器官受累病灶的检出率分别为96.7％和65.5％,分期准确率分别为92.3％和73.1％.15例(57.7％)患者因PET/CT检查改变临床分期,其中12例因发现更多病灶提高分期,3例可疑病灶因在PET/CT上无代谢而明确性质降低分期,9例因分期调整影响治疗方案的制订.结论 18F-FDG PET/CT能准确显示鼻型ENKTCL病灶的分布情况,较常规影像学检查能检测到更多淋巴结及结外器官受累,使分期更准确,从而更加有效地指导临床治疗.
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