“流动的肺泡?”——超声谐振微泡定向增加组织局部供氧的理论研究

摘要

Objective To investigate the theory of ultrasound-enhanced oxygen delivery by microbubbles. Methods According to the Fick theory, Boyle law and Dalton law, the mathematical model for O2 exchange in micorobubbles under ultrasound field was made. Results Under ultrasound field, gas exchange was enhanced and oxygen delivery was accelerated. Theoretical analysis showed that the expansion and contraction of microbubbles would accelerate the change of gas pressure and gas exchange. Conclusion Ultrasound may accelerate the balance of O2/CO2 between microbubbles and its surrounding tissues under the alternate pressure, therefore increasing Oz exchange to surrounding tissue.%目的 探讨在超声声场作用下,微泡是否可能有助于更多地向局部输送氧.方法 依据菲克第一定律、玻意耳定律及道尔顿气体分压定律,建立超声声场作用下的微泡气体交换方程和计算机模拟程序.结果 超声辐照加速了微泡内外的气体交换,促进了微泡内O2的快速向外释放.理论分析说明,在超声声场中,微泡的体积收缩和膨胀将加速其内外气体压力的变化和气体交换.结论 在高频率交变压力的作用下,超声将加速平衡微泡与周围组织的O2/CO2分压的差异,有助于向局部输送更多氧.