目的 探讨BOLD-fMRI评价原发性肝细胞癌(HCC)患者接受TACE治疗前、后的血氧变化特点及其临床应用价值.方法 对10例HCC患者(HCC组)和10名健康志愿者(对照组)进行BOLD-fMRI扫描,对HCC组患者于TACE术后2～3周内再次行BOLD-fMRI扫描.结果 HCC组和对照组肝实质T2*值分别为(13.90±2.94)ms和(17.94±5.93)ms,差异无统计学意义(P＞0.05).HCC组TACE治疗前、后富血供HCC组织T2*值分别为(31.91±2.07)ms 和(7.69±0.75)ms,差异有统计学意义(P＜0.01),TACE治疗前、后肿瘤周围肝脏组织T2*值分别为(19.94±3.05)ms 和(24.21±1.98)ms,差异有统计学意义(P＜0.01).结论 BOLD-fMRI能有效评测HCC患者TACE治疗前、后非瘤肝脏组织和肿瘤组织内血氧含量的变化特点.%To investigate the value of BOLD-fMRI in evaluating oxygenation changes in patients with primary hepatocellular carcinoma (HCC) before and after TACE. Methods Ten patients with HCC (HCC group) and 10 volunteers (control group) underwent BOLD-fMRI, and the patients with HCC underwent BOLD-fMRI examination again 2—3 weeks after TACE. Results The mean T2 value of liver tissue in HCC group and control group was (13. 90±2.94)ms and (17. 94±5. 93)ms, respectively (P>0. 05). In HCC group, the mean T2* value of tumor tissue with rich blood supply was (31.91±2. 07)ms and (7. 69±0.75)ms before and after TACE, respectively (P<0. 01), while of surrounding liver tissue was (19. 94±3. 05)ms and (24. 21±1. 98)ms, respectively (P<0. 01). Conclusion BOLD-fMRI can effectively evaluate the oxygenation changes of primary hepatocellular carcinoma before and after TACE.
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