伴认知功能障碍的颞叶癫痫MRI研究进展

摘要

颞叶癫痫(TLE)是癫痫最常见的类型,其反复发作可致患者记忆力、语言及执行力等认知功能损害,使患者生存质量进一步下降.但颞叶癫痫导致认知功能障碍的机制尚不清楚,无法进行相关治疗.随着MR和图像后处理技术的发展,采用DTI、基于体素的形态学分析(VBM)和fMRI技术研究颞叶癫痫伴认知障碍患者脑结构和脑网络变化,发现认知障碍与部分脑区的结构和功能改变具有相关性.本文对伴认知障碍的TLE患者脑结构和功能改变的研究进展进行综述.%Temporal lobe epilepsy (TLE) was the most common type of epilepsy.The cognitive function such as memory,language,executive function could be damaged due to recurrent seizures,the life quality of patients decreased further.However,the mechanism of cognitive dysfunction caused by TLE was unclear,no effective treatment could be performed.With the development of MRI and post-processing techniques,DTI,voxel based morphometry and fMRI had been employed to investigate the cerebral structure and network changes in TLE patients with cognitive impairment,which had found cognitive impairment was related to structural and functional changes in some brain regions.This paper reviewed the progresses of brain structural and functional changes of TLE with cognitive impairment.