磺胺类标准物质期间核查NMR定量方法研究

摘要

A quantitative NMR method for analyzing sulfonamides reference materials based on determination of Sulfameter content was developed.The liner range of the method was found to be 1.00～20.00 mg/mL.The regression equation derived was y=0.112 8x+0.016 2,R=0.999 0,and the relative deviation was less than 0.7％.The results of this study showed that quantitative NMR analysis provides a simple,convenient,accurate and stable method for period verification of sulfonamides reference materials.%以核磁共振技术测定标准物质磺胺对甲氧嘧啶的含量为例,建立了磺胺类标准物质期间核查NMR定量分析方法.结果得到磺胺对甲氧嘧啶在1.00～20.00 mg/mL浓度范围内具有良好线性关系,回归方程为:y=0.112 8x+0.016 2,R=0.999 0,测定结果的误差＜0.7％.结果表明,NMR定量分析方法简便、准确、稳定性好,可作为磺胺类标准物质期间核查溯源性定值分析方法.