环状RNA研究进展及其在HBV相关肝病中的作用

摘要

环状RNA（circRNAs）是内源性非编码RNA（non-coding RNA，ncRNA）和竞争性内源RNA （competing endogenous RNA，ceRNA）家族的新兴成员。circRNAs通过特殊的前体mRNA可变剪接，以外显子或内含子环化的形式将3’端和5’端通过共价键连接起来，形成一个闭合环状结构。目前研究表明circRNAs广泛存在于生物体中，可通过与miRNA和蛋白质等其他分子相互作用调控基因的表达并参与疾病的发生和发展，其有望在疾病的预防、诊断及治疗中发挥重要的作用。本文就目前circRNAs研究进展及其在HBV相关肝病中的作用进行综述。%Circular RNA (circ RNAs) is a novel type of non-coding RNA (ncRNA) and competing endogenous RNA (ceRNA), who forms covalently closed loop structure by jointing 3’ and 5’ends together via exon circularization and intron circularization. Current studies have discovered that circRNAs are widely expressed in eukaryocyte and act as regulator of gene expression by interacting with miRNA, proteins and other molecules. Emerging evidence indicates that circRNA plays the essential role in the development of some diseases and may serve as diagnostic or predictive biomarkers. Herein, we reviewed the current available outcomes and progress of researches concerning circRNAs and the potential relationship between HBV-related liver diseases and circRNAs.