慢性乙型肝炎患者血清IL-2、IL-4、IL-10及IFN-γ水平与肝组织病理的相关性

摘要

Objective To investigate the relationship between serum levels of IL-2,IL-4,IL-10 and IFN-γ and hepatic tissue pathology in patients with chronic hepatitis B.Methods Total of 90 cases with chronic hepatitis B (CHB) in Gezhouba Central Hospital from January 2010 to December 2015 were selected.All patients were underwent liver biopsy and the serum levels of IL-2,IL-4,IL-10 and IFN-γ were detected.The relationship between the above indexes and hepatic tissue pathology were analyzed.Results The number of patients with CHB in G1 ～G4 stage were 24,23,21 and 23,respectively.The serum levels of IL-2,IL-4,IL-10 and IFN-γ in patients with different hepatic inflammatory activity were statistically different (F =42.6,58.2,52.3,36.2;P =0.006,0.005,0.007,0.008),and were negatively related with hepatic inflammatory activity (r =-0.596,-0.609,-0.632,-0.621;P =0.007,0.006,0.005,0.006).The number of patients with CHB in S1～S4 stage were 25 cases,25 cases,20 cases and 20 cases,respectively.The serum levels of IL-2,IL-4,IL-10 and IFN-γ in patients with different liver fibrosis stage were statistically different (F =53.2,58.7,56.2,35.5;P =0.006,0.005,0.007,0.008),and were negatively related with liver fibrosis stage (r =-0.625,-0.608,-0.643,-0.632;P =0.007,0.006,0.008,0.007).Conclusion The serum levels of IL-2,IL-4,IL-10 and TFN-γ in patients with CHB were negatively related with hepatic inflammatory activity and liver fibrosis stage.%目的 探究慢性乙型肝炎患者血清IL-2、IL-4、IL-10、IFN-γ活性与肝组织病理的相关性.方法 选取2010年1月至2015年12月于葛洲坝中心医院住院的90例慢性乙型肝炎(CHB)患者为研究对象,测定所有患者血清IL-2、IL-4、IL-10和IFN-γ水平并同步进行肝组织活检,分析上述各指标与肝组织病理的相关性.结果 90例CHB患者中,肝组织炎症活动度Gl～G4期分别有24例、23例、21例、23例,不同肝组织炎症活动度患者血清IL-2、IL-4、IL-10及IFN-γ水平的差异有统计学意义(F值分别为42.6、58.2、52.3、36.2,P值分别为0.006、0.005、0.007、0.008),与肝组织炎症活动度呈负相关(r值分别为-0.596、-0.609、-0.632、-0.621,P值分别为0.007、0.006、0.005、0.006).90例CHB患者中肝纤维化分期S1～S4分别有25例、25例、20例、20例,不同肝纤维化分期患者血清IL-2、IL-4、IL-10和IFN-γ水平的差异有统计学意义(F值分别为53.2、58.7、56.2、35.5,P值分别为0.006、0.005、0.007、0.008),与肝纤维化程度均呈负相关(r值分别为-0.625、-0.608、-0.643、-0.632,P值分别为0.007、0.006、0.008、0.007).结论 CHB患者血清IL-2、IL-4、IL-10及IFN-γ水平与肝组织炎症活动度和肝纤维化程度均呈负相关.