HBV X蛋白调控微小RNA致肝细胞癌发生机制的进展

摘要

微小RNA (miRNA)是片段长度约为22个核苷酸的高度保守的内源性非编码单链小RNA,广泛存在于动植物及病毒体内.成熟的miRNA通过使靶基因mRNA降解或特异性翻译抑制从而调节靶基因的表达,广泛参与生物体内的生理和病理过程.乙型肝炎病毒(HBV)X蛋白(HBX)是HBV病毒X基因编码的相对分子质量约为17000的蛋白质,与肝细胞癌的发生发展密切相关.近年来研究发现一些特异的miRNA受HBX调控,参与调节肝癌细胞的增殖、分化和凋亡等多个生物学过程.%MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs of-22 nucleotides that exist in a wide variety of organisms,including animals,plants and virus.Mature miRNAs are able to control gene expression at a post-transcriptional level,either by blocking mRNA translation or inducing their degradation.Hepatitis B virus X protein (HBX) is a 17000 protein that is implicated to play a crucial role in hepatocarcinogenesis.Recently,many studies have shown that HBX is associated with miRNA regulation,and is involved in regulating fundamental biological processes of tumor in cell proliferation,differentiation and apoptosis.