Objective Using the third high sensitive cardiac troponin I assay to establish the reference intervals of serum cardiac marker high sensitivity cardiac troponin I ( hs-cTnI ) in apparently healthy subjects of Beijing area, and to explore the relationship between cTnI and other parameters.Methods Using random selection method, a total of 440 serum samples were collected from apparently healthy subjects of Beijing area.Among them, 217 cases were male, average age was (50.0 ±14.3) years old;223 cases were female, average age was ( 49.0 ±14.0 ) years old.All of these serum samples were detected hs-cTnI using i2000 Abott biochemical analyzer and ARCHITECT STAT Abbott assay kit.And the 99th percentile upper reference limit was used as the reference interval.Non-parametric tests were used to compare the different groups, the U Mann-Whitney test was used between two groups, the Kruskal-Wallis test was used in many groups, and the correlation analysis was used Spearman method.Results The 99th percentiles of hs-cTnI in 440 apparently healthy subjects is 9.66 ng/L.While the male group is 9.66 ng/L, and the female group is 8.25 ng/L.The serum hs-cTnI level of male is higher than female ( 9.95 ng/L vs 8.25 ng/L, P<0.05 ).According to the spearman correlation analysis, the serum hs-cTnI level appears positive correlation with age, brain natriuretic peptide (BNP), alanine aminotransferase (ALT),aspartate transaminase ( AST) ,gamma-glutamyl transferase ( GGT) ,total bilirubin ( TBIL) ,serum creatinine ( SCR) , hemoglobin (HGB)(P<0.05,R>0),and appears negative correlation with platelet (PLT)(P<0.05,R<0).Conclusion The serum hs-cTnI level apparently differents with gender, so it is necessary to establish reference intervals among different gender group of Beijing area.%目的：探讨北京地区表观健康成年人群中血清高敏肌钙蛋白I （ hs-cTnI）参考范围的建立，并分析hs-cTnI水平与其他常用临床检测指标间的相关性。方法采用随机选取法选取2015年1至6月在首都医科大学附属北京安贞医院进行健康体检的表观健康人群440名，其中男性217名，平均年龄（50.0±14.3）岁；女性223名，平均年龄（49.0±14.0）岁。 hs-cTnI采用Abott i2000生化分析仪及Abbott ARCHITECT STAT hs-cTnI assay配套试剂盒进行检测。以研究对象的第99％分位值作为hs-cTnI参考范围。组间比较采用非参数检验，两组间比较采用Mann-Whitney U检验，多组间比较采用Kruskal-Wallis检验，相关分析采用Spearman方法。结果440名表观健康人群的第99％分位值为9.66 ng／L，男性成年人为9.95 ng／L，女性成年人为8.25 ng／L。其中男性人群第99％分位值的血清hs-cTnI显著高于女性（9.95 ng／L与8.25 ng／L， P＜0.05）。 Spearman相关分析显示，血清hs-cTnI与年龄、B型尿钠肽（BNP）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰基转移酶（GGT）、总胆红素（TBIL）、血肌酐（SCR）、血红蛋白（HGB）呈正相关（P＜0.05，R＞0），与血小板（PLT）呈负相关（ P＜0.05，R＜0）。结论血清hs-cTnI水平在不同性别的表观健康人中具有显著差异；建议不同性别的北京人群中分别建立hs-cTnI参考范围。
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