竞争性内源性RNA与胃癌发病机制研究进展

摘要

Recent studies demonstrate that the long non-coding RNAs (lncRNAs), pseudogenes, circular RNAs (circRNAs) and so on can be used as competitive endogenous RNAs (ceRNAs), binding to microRNAs (miRNAs), to regulate the expression level of their targets.This novel interplay optimizes traditional liner "miRNA→RNA" pattern and has become a research hotspot in the scientific community.Dysregulation of ceRNA interplay will influence the body′s normal life activities, leading to the occurrence of diseases, and even tumor formation.This article briefly introduces the key components of ceRNA crosstalk and its research progress in gastric cancer pathogenesis, so as to provide a new thought for cancer research, clinical diagnosis and therapeutics.%最近研究认为长链非编码RNA(lncRNA)、假基因(pseudogenes)、环状RNA(circRNA)等可以作为竞争性内源性RNA(ceRNA),结合微小RNA(miRNA),调控靶蛋白水平.这一新型的网络调控模式,优化了传统意义上的"由miRNA到RNA"线性作用方式,已然成为非编码RNA领域的研究热点.ceRNA网络调控异常,则会影响机体正常的生命活动,导致疾病的发生乃至肿瘤的形成.本文综述了ceRNA的主要成员及其参与胃癌发生机制的研究进展,以期为胃癌研究及临床诊断、治疗等提供新思路.