基质金属蛋白酶MMP-2在口腔鳞癌中的表达及意义

摘要

目的 分析基质金属蛋白酶(MMP-2)在口腔鳞癌中的表达及与临床病理之间的关系,为口腔鳞癌的诊断提供一个新的指标.方法 收集50例手术临床病理证实口腔鳞癌手术标本.用免疫组化法检测MMP-2的表达.数据资料应用SPSS17.0统计学软件处理.结果 MMP-2的表达水平与口腔鳞癌淋巴结转移有关、有统计学意义(P<0.05),与口腔磷癌组织学类型、分化程度无关(P>0.05).结论 MMP-2可以作为评价口腔鳞癌侵袭和转移能力指标.%Objective To observe the expression of M atrix M etalloproteinase-2 in Oral Squam ous Cell Carcinom and their relationships with clinicopathologic features.To support a new predictive and a new pathway to the treatment of the rectal carcinoma.Methods In this research 50 paraffin-embedded cancer biopsy specimens of patients with rectal carcinom a who had been proved to have Oral Squam ous Cell Carcinom through pathological diagnosis and had operation for cure Routine slice is done for 2 serial section in 3 m thickness ,and used to detect the expression level of MMP-2 with the appliance of SP.The data have been statistically analyzed with spss 13.0 for windows.Results And there are no significant statistical differences in MMP-2 expressions among the tumorlocation ,growth style,histological type,differentiated degrees of the patients respectively(p＞0.05).There are significant differences in MMP-2 expression in Lymphnode metastasis(P＜0.05).Conclusion MMP-2 can be used to appraise the latent energy of invasion and metastasis in Oral Squam ous Cell Carcinoma.