Ⅰ型胶原吡啶交联终肽(ICTP)在原发性骨肿瘤中的应用

摘要

Objective To explore the clinical usefulness of determ ination of serum pyridinoline cross-linked carboxyterm inal telopeptide of Type I Collagen (ICTP) in patients with pri(m) ary malignant bone tum or and benign bone tum or .Methods Serum ICTP in 42 m alignant bone tum or patients and 34 benign bone tumm or patients were analyzed .Serum ICTP was determ ined by enzym e inmunoassay (EIA ) .ResuIts The serum level of ICTP shcwn (16.91±10.73) μg/L in m alignant bone tum or group was significantly higher than those of the control group ( P＜0.01 ) .The srum level (5.70± 4.40 )μg/L in benign bone tum or group has no significantly statistics com pared w ith the control group ( P＞0.05 ) .A t the sam e tim e ,the serum level in m alignant bone tum or group w ere significantly higher than that of benign bone tum or group ( P＜0.01 ) .C onclusion Serum ICTP was a sensitive and convenientbiochem ical index which could diagnose and identify prim ary bone tum or.%目的 探讨血清Ⅰ型胶原吡啶交联终肽(ICTP)在原发性恶性骨肿瘤和原发性良性骨肿瘤中的临床应用价值.方法 对本院骨肿瘤科收治的42例原发性恶性骨肿瘤,34例良性骨肿瘤患者,采用酶免疫测定(EIA)方法测定ICTP水平.结果 原发性恶性骨肿瘤组的ICTP水平为16.91±10.73 μg/L,与健康对照组比较差异有统计学意义(P＜0.01).而良性骨肿瘤组ICTP水平为5.70±4.40 μg/L,与对照组相比差异无统计学意义(P＞0.05).良、恶性骨肿瘤组间差异也有统计学意义(P＜0.01).ICTP对骨肿瘤的敏感性和特异性分别为85%和53%.结论 血清ICTP可作为原发性骨肿瘤诊断及鉴别诊断的一个指标.