Objective To discuss the relationship of serum PSA, ALP, ICTP and prostate cancer with bone metastasis ,and its diagnostic significance on prostate cancer with bone metastasis. Methods 98 cases with prostate cancer were divided into 45 cases of control group (without bone metastasis) and 53 cases of observation group (with bone metastasis) according to bone imaging. The expression of serum PSA, ALP and ICTP were detected by chemiluminescence im-munoassay and ELISA. The relationship with prostate cancer with bone metastasis and its diagnostic value on bone metastasis were analyzed. Results The value of PSA, ALP and ICTP in observation group were obviously higher than that in control group (P<0. 05). 20 μg/L was taken as critical value of PSA,its sensitivity,specificity and accuracy were 96. 23%(51/53),55. 56%(25/45) ,85. 71% (84/98) respectively; 90μg/L was taken as critical value of ALP,its sensitivity, specificity and accuracy were 94. 34% (50/53) , 46. 67% (21/45) , 72. 45% (71/98) , respectively; 6μg/L was taken as critical value of ICTP, its sensitivity, specificity and accuracy were 98. 11% (52/53) ,86. 67% (39/45) ,91/98 (92. 86%) respectively. Conclusion Serum PSA, ALP and ICTP can be regarded as reliable index for the diagnosis of prostate cancer with bone metastasis. They can show the degree of bone metastasis and evaluate the treatment effect.%目的 探讨血清中PSA、ALP及ICTP与前列腺癌骨转移的关系以及对前列腺骨转移的诊断意义.方法 我院泌尿科确诊的98例前列腺癌患者,根据骨显像将98例前列腺癌患者分对照组(非骨转移)45例和观察组(骨转移)53例,采用化学发光免疫分析法和ELISA检测两组患者血清中PSA、ALP及ICTP的表达,分析ALP、PSA及ICTP与前列腺癌骨转移的关系及对骨转移的诊断价值.结果 观察组ALP、PSA及ICTP明显高于对照组(P＜0.05),PSA值以>20μg/L为临界值其灵敏度、特异性和准确性分别为96.2%(51/53)、60.0%(27/45)、80.6%(79/98);ALP值以>90 U/L为临界值其灵敏度、特异性和准确性分别为94.3%(50/53)、46.7%(21/45)、72.4%(71/98);ICTP值>6μg/L为临界值其灵敏度、特异性和准确性分别为98.1%(52/53)、86.7%(39/45)、92.9%(91/98).结论 血清PSA、ALP及ICTP均可作为诊断前列腺癌骨转移的可靠指标,并反映骨转移的程度以及评价治疗效果.
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