Objective To investigate the scrum AFP,CA199 ,CEA) ,y-g1utamy1 peptidase (GGT) and CA125 combined detection of primary liver cancer diagnosis and prognosis of the disease,and other aspects of clinical value. Methods January 2009 to 2011 a period pathologically diagnosed 32 cases of primary liver cancer and 36 cases of hepatitis, cirrhosis and 30 healthy subjects as the object of observation in each group were measured in scrum AFP,CA199 ,GGT and CA125 levels,and application of statistical methods for comparative analysis. Results Primary liver cancer patients AFP,CA199,GGT and CA125 levels were significantly higher than the cirrhosis group and control group,the difference was statistically significant (P<0. 05). AFP,CA199 ,GGT and CA125 combined detection sensitivity were higher than that of monitoring indicators,the difference was statistically significant (P<0. 05). Conclusion Combined detection of scrum CEA,CA50 ,CA19-9 ,CA125 for primary liver cancer disease assessment, treatment and prognosis of such evaluation has some clinical value,and diagnostic sensitivity than single-target detection.%目的 探讨血清AFP、CA199、γ-谷氨酰转肽酶(GGT)和CA125联合检测对原发性肝癌的诊断、病情及和预后评估等方面的临床价值.方法 选取2009年1月-2011年1月经术后病理确诊32例原发性肝癌患者和36例肝炎肝硬化者以及30例健康体检者作为观察对象,分别检测各组的血清AFP、CA199、GGT和CA125水平,并应用统计学方法进行对比分析.结果 原发性肝癌患者血清AFP、CA199、GGT和CA125水平明显高于肝硬化组、对照组,差异有统计学意义(P＜0.05).AFP、CA199、GGT和CA125联合检测的敏感性高于单一监测指标,差异有统计学意义(P＜0.05).结论 联合检测血清CEA、CA50、CA19-9、CA125对原发性肝癌的病情评估、疗效评价和预后评估等方面具有一定的临床价值,且诊断的敏感性高于单一指标检测.
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