孕晚期妇女宫颈分泌物病原菌的分布和耐药分析

摘要

Objective To investigate the distribution and drug resistance of bacteria in the cervical secretions of the third trimester of pregnancy.Methods 755 cases of pregnant women in our hospital from March 2010 to May were se-lected,Routine bacteria identification and drug sensitivity test of cervical secretion,Analysis of bacteria distribution and drug resistance of cervical pathogens in the third trimester of pregnancy.Results 182 strains of pathogenic bacteria (24.11%)were detected,Among them,79 strains (43.41%)were gram-negative bacilli(G- ),Escherichia coli 36 strains(45.57%),Klebsiella pneumoniae 19 strains(24.05%);100 strains of gram positive bacteria(54.95%),Staphy-lococcus aureus 39 strains(39%),30 strains of coagulase negative staphylococcus(30%);3 strains of fungi were detec-ted(1.65%).G+ cocci to nitrofurantoin,rifamycin,levofloxacin,vancomycin highest sensitivity;G- bacilli to imipen-em,Amikacin,nitrofurantoin,piperacillin/tazobactam with highest sensitivity.Conclusion The distribution of bacterial flora in the cervix of women in the third trimester of pregnancy is wide,High resistance rate,should cause clinical atten-tion.%目的：探讨孕晚期妇女宫颈分泌物携带病原菌的分布和耐药分析。方法选择我院2010年3月-2015年5月产科诊治的755例孕晚期妇女，对宫颈分泌物进行常规细菌鉴定以及药敏试验，分析孕晚期妇女宫颈病原菌的菌群分布及耐药性。结果共检出病原菌182株（24．11％），其中革兰阴性杆菌（G－杆菌）79株（43．41％），以大肠埃希菌36株（45．57％）、肺炎克雷伯菌19株（24．05％）多见；革兰阳性球菌（G＋球菌）100株（54．95％），以金黄色葡萄球菌39株（39％）、凝固酶阴性葡萄球菌30株（30％）多见；检出3株真菌（1．65％）。G＋球菌对呋喃妥因、利福霉素、左旋氧氟沙星、万古霉素敏感性最高；G－杆菌对亚胺培南、阿米卡星、呋喃妥因、哌拉西林／他唑巴坦敏感性最高。结论孕晚期妇女宫颈携带病原菌菌群分布广，耐药率高，应引起临床重视。