急性脑梗死患者血清和肽素、NT-proBNP水平变化及其临床意义

摘要

Objective To observe the changes in serum level of NT-proBNP,and the peptide in patients with acute cerebral infarction,explore the relationship between disease and acute cerebral infarction and its clinical significance. Methods 92 cases of patients with acute cerebral infarction neurological department of Internal Medicine * * hospital as the research object,90 cases of healthy people to participate in the examination of the hospital during the same period as the control group,collect their general information respectively,determination of pigment,NT-proBNP content in se-rum and peptide,the difference in serum and peptide were compared between the two groups of objects and the severity of acute cerebral infarction,NT-proBNP level changes.Results Mild group and severe group of acute cerebral infarc-tion’s copeptin and NT-proBNP was higher than the control group of subjects,the difference was statistically signifi-cant(P <0.05);Severe acute cerebral infarction patients 24 hours after admission,7 days,14 days of serum copeptin levels were significantly higher than that in patients with mild,the difference was statistically significant(P <0.05);The concentration of NT-proBNP in patients with severe hospital group 24 hours,7 days was significantly higher than the mild group,the difference was statistically significant(P <0.05),there was no significant difference between the two groups NT-proBNP 14 days(P >0.05).Conclusion The level of copeptin、NT-proBNP in patients with acute cere-bral infarction was higher than the control group,associated with the onset and severity of acute cerebral infarction,to observe the change of copeptin and NT-proBNP level,contribute to clinical diagnosis and treatment of acute cerebral in-farction.%目的：观察急性脑梗死患者血清和肽素、NT-proBNP 水平变化情况，探讨两者与急性脑梗死病情的关系及其临床意义。方法选择我院神经内科92例急性脑梗死患者作为研究对象，同期来医院参加体检的90例健康人作为对照组，分别收集他们的一般资料，测定其血清和肽素、NT-proBNP 含量，比较两组研究对象及不同病情急性脑梗死患者血清和肽素、NT-proBNP 水平变化的差异。结果急性脑梗死轻症组、重症组患者的血清和肽素和 NT-proB-NP 水平高于对照组，差异有统计学意义（P ＜0．05）；急性脑梗死重症组患者入院24小时、7天、14天血清和肽素水平分别显著高于轻症组患者对应时间的血清和肽素水平，差异有统计学意义（P ＜0．05）；重症组患者入院24小时、7天的 NT-proBNP 浓度明显高于轻症组患者，差异有统计学意义（P ＜0．05），两组14天的 NT-proBNP 差异无统计学意义（P＞0．05）。结论急性脑梗死患者血清和肽素、NT-proBNP 水平升高，与急性脑梗死病情、发病时间有关，观察血清和肽素、NT-proBNP 水平变化有助临床急性脑梗死的诊断和治疗。