溃疡性结肠炎患者中神经肽Y的检测意义分析

摘要

目的 探讨溃疡性结肠炎患者中神经肽Y(NPY)的检测意义.方法 2013年8月到2016年2月选择在我院诊治的区78例溃疡性结肠炎患者作为病例组,同期选择健康体检者78例作为对照组,两组都进行血清NPY与相关胃肠激素的检测,同时进行临床症状评分与心理状况的评定,然后进行相关性分析.结果 病例组的血清NPY含量为41.22±11.48 pg/ml,而对照组为62.45±13.98 pg/ml,病例组明显低于对照组(P＜0.05);同时病例组的血清MLT、LEP、VIP含量与对照组对比差异也有统计学意义(P＜0.05).病例组与对照组的症状评分分别为21.53±5.23分和3.20±1.48分,病例组明显高于对照组(t=43.1223,P＜0.05).病例组的SDS与SAS评分都明显高于对照组,对比差异有统计学意义(P＜0.05).Spearman相关检验分析表明病例组的血清NPY含量与症状评分、SAS评分、SDS评分呈现明显负相关性(P＜0.05),而与血清MLT、LEP、VIP含量呈现明显正相关性(P＜0.05);非条件logistic回归计算显示NPY、SAS、SDS和LEP为导致溃疡性结肠炎发生的主要危险因素(P＜0.05).结论 溃疡性结肠炎患者中神经肽Y呈现低表达状况,且与患者的病情、心理状况与胃肠激素表达状况明显相关,NPY可能成为调节溃疡性结肠炎发生与发展的新靶点.%Objective To explore the significance of detection of neuropeptide Y(NPY) in patients with ulcerative colitis.Methods From August 2013 to 2016 February in our hospital,selected 78 cases of ulcer colitis patients as case group,selected 78 healthy cases as control group at the same period,two groups were given the detection of serum NPY and gastrointestinal hormone,and evaluation of clinical symptom score and mental status,and correlation analysis.Results The serum NPY contents in the case group were 41.22±11.48 pg/ml,while the control group were 62.45 ± 13.98 pg/ml that the case group were significantly lower than control group (P＜0.05);and the serum MLT,LEP,VIP content in the case group compared to the control group differences were also statistically significant(P＜0.05).The symptom scores in the case group and the control group were 21.53±5.23 points and 3.20±1.48 points that the case group were significantly higher than the control group (t=43.1223,P＜0.05).The SDS and SAS scores of thecase group were significantly higher than the control group (P＜0.05).The Spearman correlation test analysis showed that the serum NPY levels in the case group were significant negative correlated to the symptom score,the scores of SAS,SDS (P＜ 0.05),and showed significant positive correlation to the serum MLT,LEP,VIP contents (P＜0.05);Non conditional logistic regression calculations show that NPY,SAS,SDS and LEP as the main risk factors for the occurrence of ulcerative colitis (P＜ 0.05).Conclusion neuropeptide Y in patients with ulcerative colitis presents low expression and the patient's condition,mental status and gastrointestinal hormone expression status are significantly related to NPY may be regulation of the occurrence of ulcerative colitis and development of a new target.