支原体肺炎患者中性粒细胞碱性磷酸酶、急性时相反应蛋白及细胞因子检测的临床意义

摘要

目的 探讨支原体肺炎患者中性粒细胞碱性磷酸酶、急性时相反应蛋白及细胞因子检测的临床意义.方法 选取2015年12月-2016年10月期间我院收治的肺炎患者212例为研究对象,对感染支原体的临床危险因素进行统计分析,同时对支原体感染患者和非感染患者的中性粒细胞碱性磷酸酶、急性时相反应蛋白及细胞因子指标进行比较分析.结果 212例肺炎患者中支原体肺炎患者98例,支原体感染率为46.23％;年龄、低补体状态、流行接触史、IgM阳性结节影、磨玻璃样影、树芽征是影响肺炎支原体感染的独立危险因素;支原体肺炎患者急性期和恢复期的急性时相反应蛋白和中性粒细胞碱性磷酸酶均显著高于非原体肺炎患者,且差异有统计学意义(P<0.01);支原体肺炎患者的各项细胞因子指标均显著高于非支原体肺炎患者,且差异有统计学意义(P<0.01).结论 年龄、低补体状态、流行接触史、IgM阳性、结节影、磨玻璃样影、树芽征是影响支原体肺炎患者发病的危险因素,中性粒细胞碱性磷酸酶、急性时相反应蛋白及细胞因子水平变化与支原体肺炎的发生发展有关,针对上述指标的检测有助于临床上的鉴别诊断.%Objective To investigate the risk factors of mycoplasma pneumonia and the changes of neutrophil alka-line phosphatase,acute phase reaction protein and cytokines in patients with mycoplasma pneumonia.Methods 212 pa-tients with pneumonia in our hospital from December 2015 to October 2016 were chosen as the research object.The clinical risk factors of mycoplasma infection were analyzed statistically.The neutrophil alkaline phosphatase,acute phase response protein and cytokine markers of the mycoplasma infection and non-infected patients were observed and com-pared.Results 98 cases were with mycoplasma pneumonia in the 212 cases of pneumonia,and the mycoplasma infection rate was 46.23％.Age,low complement status,epidemiological exposure history,IgM positive nodules,ground glass o-pacities,and bud buds were the independent risk factors affecting Mycoplasma pneumoniae infection.The acute phase response protein and neutrophil alkaline phosphatase of mycoplasma pneumonia in patients with acute and convalescence were significantly higher than non-original pneumonia patients,and the differences were with statistical significance(P<0.01).The cytokine markers of mycoplasma pneumonia in patients were significantly higher than non-original pneu-monia patients,and the differences were with statistical significance (P<0.01).Conclusion Age,low complement sta-tus,epidemic contact history,IgM positive,nodular shadow,ground-glass-like shadow and bud buds are the risk factors of pathogenesis of mycoplasma pneumonia.The neutrophil alkaline phosphatase,acute phase reaction protein and chan-ges in cytokine levels is related with the occurrence and development of mycoplasma pneumonia.Detection of the above indicators will help the clinical differential diagnosis.