肝癌射频消融后肝脓肿的发生率及危险因素分析

摘要

目的 探讨肝癌射频消融(RFA)后肝脓肿形成的发生率及危险因素.方法 回顾性分析2000年1月-2016年6月接受RFA治疗的1 643例肝癌患者的资料,包括原发性肝细胞癌(HCC) 942例、胆管细胞癌(CCC)31例、转移性肝癌(MLC)670例,采用Logistic回归对影响因素进行分析.结果 肝癌RFA治疗后肝脓肿发生率为0.79％(13/1 643).单因素分析显示,糖尿病史、肝功能Child-Pugh分级、手术史及肿瘤位置与肝癌RFA治疗后肝脓肿形成相关(P均＜0.05);多因素分析显示,糖尿病史、手术史及肿瘤位置为肝癌RFA治疗后肝脓肿形成的独立危险因素.结论 糖尿病史、手术史、肿瘤位置是影响肝癌RFA治疗后肝脓肿形成的重要因素.%Objective To investigate the incidence and risk factors of liver abscess after radiofrequency ablation (RFA) for liver cancer.Methods A retrospective study was performed on 1 643 patients from January 2000 to June 2016.All the patients were diagnosed with hepatocellular carcinoma (HCC,n =942),cholangiocellular carcinoma (CCC,n =31) or metastatic liver carcinoma (MLC,n=670).Univariate and multiple Logistic regression analysis were used to evaluate the risk factors of liver abscess.Results The incidence of liver abscess after RFA was 0.79％％ (13/1 643).Univariate analysis indicated that the liver abscess was significantly correlated with the history of diabetic mellitus (DM),Child-Pugh level,history of surgery and tumor location (all P＜0.05).Multivariate analysis showed that the history of DM,history of surgery and tumor location were independent risk factors of liver abscess after RFA for liver cancer.Conclusion History of DM,surgery and tumor location are important factors that result in liver abscess after RFA.