DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIATION THERAPY USING THE SAME

摘要

Disclosed are a DNA chip and a prediction method for predicting the occurrence of a late adverse reaction in a urinary organ after C-ion RT. The DNA chip comprises a supporting means for supporting a DNA probe thereon; and two or more genetic markers supported on the supporting means. The prediction method comprises: a first step of hybridizing a genetic marker with labeled DNA prepared from a subject to be examined; a second step of identifying nucleotides of both alleles of the labeled DNA hybridized with the genetic marker; and a third step of determining the combination of the identified nucleotides of both alleles of the labeled DNA as being a risk genotype when the combination of the identified nucleotides corresponds to a specified combination, and predicting that the subject is predisposed to develop a late adverse reaction in a urinary organ after radiation therapy when the number of the risk genotypes is three or more and that the subject is not predisposed to develop a late adverse reaction in a urinary organ after radiation therapy when the number of the risk genotypes is two or less. The method enables to predict whether or not a subject is affected with a late adverse reaction in a urinary organ after radiation therapy.