冠状动脉支架置入术对冠心病患者C反应蛋白及肌钙蛋白T的影响

摘要

Objective　C-reactive protein (CRP) is a sensitive indicator of inflammation, and recent studies have showed that CRP is a risk factor for a poor outcome of coronary angioplasty. The aim of the study was to examine the effect of coronary stenting on blood levels of CRP and evaluate the association between blood CRP and troponin T (TnT). Methods　Sixty-four patients who underwent coronary stenting from January to April, 1999, were included in this study, and 28 patients who received coronary angiography during the same period were selectecd as controls. Blood samples for measurement of CRP and TnT were taken in the early morning of the procedure and the followed early morning after the procedure. Results　In patients with coronary stenting, CRP levels after the procedure were significantly higher than that before the procedure (P=0.01), but blood levels of TnT after the procedure were not significantly higher than that before the procedure (P=0.32). In patients with angiography, bot hCRP and TnT levels after angiography were not significantly higher than those before angiography (P>0.05). Conclusion　Coronary stenting causes a detectable increase in blood levels of C-reactive protein. The increase might not be secondary to myocardial injury, but simply reflect the intrinsic inflammation or tissue damage within the arterial lesions treated with stenting.%目的评价经皮冠状动脉支架置入术(CS)对血液C反应蛋白(CRP)及肌钙蛋白T(TnT)的影响，并探讨CRP与TnT的关系。方法选择1999年1月至4月在我院行CS的患者为研究对象(n=64),同时选择一组同期进行冠状动脉造影(CAG)的患者作为对照(n=28)。分别于CS或CAG术当天及术后第二天清晨采集空腹血进行血液CRP及TnT水平的测定。结果 CS组患者术后血清CRP水平显著高于术前(P=0.01)；TnT水平与术前比较差别无显著性(P=0.32)。CAG组患者，造影后血液CRP及TnT水平与造影前比较差别均无显著性(P>0.05)。结论冠状动脉支架置入术后血液CRP水平升高。CRP的升高不是心肌坏死所引起，而可能是CS治疗局部炎症反应的一种表现。