Effects of 4 Percent and 6 Percent Carboxyhemoglobin on Arrhythmia Production inPatients with Coronary Artery Disease

摘要

A study used a randomized, double-blind, crossover design to assess the effectsof exposure to carbon monoxide (CO) resulting in 4% or 6% carboxyhemoglobin (COHb) on ventricular arrhythmias in 41 subjects (nonsmokers) with documented coronary artery disease. Subjects were exposed to room air, 100 ppm CO (target, 4% blood COHb), or 200 ppm CO (target, 6% blood COHb), and then did a supine bicycle exercise test. Radionuclide ventriculography was performed at rest and during exercise. Ambulatory electrocardiogram recordings were made to determine the frequency of premature ventricular contractions (PVCs). The frequency of single and multiple PVCs per hour during exercise was significantly greater on