Objective To study the suitable dose of intracoronary adenosine (AD) on fractional flow reserve (FFR) measurement in Chinese patients with angiographic coronary artery disease. Methods FFR was measured in 32 patients with 40 moderate coronary stenosis. Boluses of intracoronary AD at increasing doses of 60μg (A1), 80μg (A2), 100μg (A3) and 120μg (A4) were randomly administered. FFR values, symptoms, systemic effects and development of atrioventricular block were recorded. Results FFR value decreased significantly by 8.99%(A1), 11.24%(A2), 13.48%(A3) and 13.48%(A4) compared with the baseline distal coronary pressure/aortic pressure (0.891±0.044, all P<0.001). A3 and A4 showed significantly lower FFR values than A1 (t=6.331、6.343, all P < 0.001),A2 (t=2.974、3.058, P=0.005、0.004). Positive rates of an FFR of<0.75 were 30.0%(n=12), 32.5%(n=13), 35.0%(n=14) and 35.0%(n=14) in A1, A2, A3 and A4. A total of 13 patients(40.6%) reported at least one side effects. Conclusions This study suggests a dose-response relationship for intracoronary AD on the measurement of FFR in Chinese patients with angiographic coronary artery disease. The suitable dose of bolus of intracoronary AD is 100μg.%目的：探讨对中国冠心病人群测定冠状动脉血流储备分数（fractional flow reserve, FFR）中冠状动脉内弹丸式注射腺苷（adenosine, AD）的合适剂量。方法以32例冠心病患者的40支中度狭窄病变冠状动脉血管为研究对象，将60μg（A1）、80μg（A2)、100μg（A3）和120μg（A4）的AD随机以弹丸式注入靶血管进行FFR测定。记录FFR值、注射后不良反应、血流动力学改变及是否存在房室传导阻滞。结果注射后FFR值由基础的0.891±0.044明显下降了8.99%（A1）、11.24%（A2）、13.48%（A3）和13.48%（A4）（均P＜0.001）。A3和A4则比A1（t＝6.331、6.343，均P＜0.001）、A2（t＝2.974、3.058，P＝0.005、0.004）更低。各剂量组分别有12支（30.0%）、13支（32.5%）、14支（35.0%）和14支（35.0%）靶病变的FFR＜0.75。13例（40.6％）患者出现了AD相关不良反应。结论在我国冠心病人群冠状动脉内弹丸式注射AD与FFR测定值具有明显的剂量依赖性，合适的剂量是100μg。
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