现场分诊对急性ST段抬高心肌梗死患者首次医疗接触至使用器械时间及预后的影响

摘要

Objective To determine whether field triage would reduce median contact-to-device ( C2D ) time in patients with ST-segment elevation acute myocardial infarction ( STEMI ) . Methods Consecutive patients with STEMI underwent primary percutaneous coronary intervention( PCI) from March 2010 to February 2014 in Shanghai Pudong Gongli Hospital were analyzed. Patients were divided into two groups. A total of 121 patients were admitted by field triage and 101 patients by non-field triage. The primary study point was C2D time and the study points secondary included ( door-to-balloor, D2B) time, peak Troponin I ( TnI) levels, hospital mortality and 30 days follow-up mortality. Results Baseline and procedural characteristics between the two groups were comparable. Comparing to non-field triage group, the C2D time was reduced [(92. 0 ± 56. 0)min vs. (131. 0 ± 61. 0)min,P﹤0. 01]. The D2B time was lower in the field triage group vs. the non-field triage group [(55. 0 ±26. 0)min vs. (96. 0 ±31. 0)min,P﹤0. 01]. The percentage of patients with C2D time less than 90 minutes increased significantly from 85. 1% to 98. 3%( P﹤0. 01 ) in the field triage group. Peak TnI level was significantly reduced in the field triage group [(23. 5 ±22. 0) μg/L vs. (43. 5 ± 39. 0) μg/L,P﹤0. 01]. In-hospital mortality and 30 days follow-up mortality did not significantly differ between the 2 groups (3. 3% and 3. 0%, P=0. 885;3. 3% and 5. 0%, P=0. 544, respectively). Conclusions In STEMI patients, field triage was associated with significantly reduced C2D and D2B times.%目的：探讨现场分诊能否缩短急性ST段抬高心肌梗死( STEMI)患者首次医疗接触至使用器械(C2D)时间。方法收集2010年3月至2014年2月就诊于浦东新区公利医院心内科并接受直接经皮冠状动脉介入治疗的222例STEMI患者的临床资料。根据治疗流程将患者分为两组：现场分诊组(121例)和非现场分诊组(101例)。主要分析指标为C2D时间；次要分析指标为进门至球囊扩张(D2B)时间及主要临床事件,包括肌钙蛋白I峰值、院内病死率及随访30 d病死率。结果现场分诊组患者 C2D 时间[(92.0±56.0) min 比(131.0±61.0) min,P ﹤0.01]、D2B 时间[(55.0±26.0)min比(96.0±31.0)min,P﹤0.01]显著低于非现场分诊组；现场分诊组C2D时间小于90 min的比例显著高于非现场分诊组(98.3%比85.1%,P﹤0.01)。现场分诊组肌钙蛋白I峰值显著低于非现场分诊组[(23.5±22.0)μg/L比(43.5±39.0)μg/L,P﹤0.01]。两组患者院内病死率及随访30 d病死率比较,差异均无统计学意义(均P﹥0.05)。结论现场分诊显著缩短STEMI患者C2D时间和D2B时间,并使更多的患者C2D时间小于90 min。