Objective To investigate the effects of urotensin Ⅱ (U Ⅱ ) on cardiac function and L - type calcium current in rats.and then to study the probably electrophysiological mechanism of UⅡ 's effect on the heart of rats. Methods Hearts were perfused in the Langendorff mode,and changes of cardiac function were observed after U Ⅱ was perfused in different concentrations. Whole - cell patch clamp technique was used to investigate the changes of L-type calcium current (I展开▼
