Objective To explore the effect of Xinkeshu tablet combined with angiotensin receptor blocker (ARB) on arrhythmia in patients with hypertension. Methods One hundred and sixty - seven patients with hypertensive heart disease were randomly divided into two groups: Treatment group (n=83) treated with Xinkeshu tablet and ARB, and control group (n=84) treated with placebo and ARB. Blood pressure and arrhythmia were observed at 3 months and 1 year. Results Blood pressure was controlled in two groups after treatment for 3 month. There were no significant differences between the two groups. The efficacy of atrial fibrillation, atrial premature beats, ventricular premature beats and other arrhythmias in treatment group were better than that in control group at 3 month. The efficacy was statistically significance in two groups after treatment for 1 year (P<0. 05). Conclusion Xinkeshu tablet combined with ARB can effectively control blood pressure and the atrial premature beats, ventricular premature beats, atrial fibrillation, and other arrhythmias.%目的 探讨心可舒片联合血管紧张素Ⅱ受体拮抗剂(ARB)类降压药治疗高血压心脏病致心律失常的疗效.方法 回顾总结门诊就诊的高血压心脏病患者167例,随机分为两组.治疗组83例,给予心可舒片及ARB类降压药;对照组84例,给予空白胶囊及ARB类降压药.观察患者治疗3个月和1年后血压、心律失常情况.结果 治疗3个月后,两组患者血压控制良好,并且两组之间无统计学意义,而心房纤颤、房性早搏、室性早搏等心律失常经治疗3个月后,治疗组有效率明显优于对照组,差异有统计学意义(P<0.05).结论 心可舒片联合ARB类降压药,不仅可以有效控制患者血压水平,而且能够有效改善高血压心脏病所导致的房性早搏、室性早搏、心房纤颤等心律失常.
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