平肝健脾方结合络活喜治疗青年原发性高血压临床研究

摘要

Objective To observe the clinical efficacy of Pinggan Jianpi decoction(PJD)plus amlodipine in treating the patients with young aged essential hyptension(EH).Methods Based on the enrol ed criteria,two hundreds and forty young aged patients with EH were randomly divided into the treatment group and the control group,each group was 120 patients.The treatment group was continuously given PJD plus amlodipine,and the control group were continuously given 5 mg amlodipine once a day for 12 weeks by observing syndrome changes before and after treatment as wel as changes in 24 h ambulatory blood pressure monitoring.Results The total effective rate was 91.70% in treatment group.And its efficacy syndromes had a significant effect change.Significant im-provement in the control group and its efficacy syndromes had a significant effect change.In particular,24 h ambulatory blood pres-sure monitoring had most obvious symptom improvement (P<0.0 5).The total score of clinical symptom between treamtent group and control group had significant difference (P<0.05).Conclusion PJD is significant treatment method in young aged hyperten-sive patients.%目的：观察平肝健脾方治疗青年原发性高血压的临床疗效。方法选择原发性青年高血压患者240例,随机分为治疗组和对照组,每组120例。两组均口服络活喜(5 mg,1次/日),治疗组加用平肝健脾方煎剂(1剂/日)。治疗12周后,检测两组患者血压、同型半胱氨酸水平,评价临床疗效与中医证候疗效,并于半年后随访血压情况。结果两组血压及血清同型半胱氨酸水平均较治疗前显著下降(P<0.05),其中治疗组优于对照组(P<0.05)；治疗组临床疗效总有效率为91.7%、中医证候总有效率96.7%,对照组临床总有效率为91.6%、中医证候总有效率93.1%,两者相比无统计学意义；但在改善患者动态血压水平方面治疗组优于对照组(P<0.05)。结论平肝健脾方配合络活喜治疗青年原发性高血压,较单纯应用络活喜治疗更具优势。